From 295 Northbound:

Take Exit 7 (Franklin Ave)
Bear RIGHT off the exit.
Through 4 sets of lights.
Take a right on Middle St.
Through one set of lights.
Take a LEFT on Exchange St.
Take next LEFT on Milk St.
Take next LEFT on Market St.
The BIG EASY in on your right.
From 295 Southbound:

Take Exit 7 (Franklin Ave)
Through 4 sets of lights.
Take a right on Middle St.
Through one set of lights.
Take a LEFT on Exchange St.
Take next LEFT on Milk St.
Take next LEFT on Market St.
The BIG EASY in on your right.